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Overview
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Serine296/Serine297 is a major phosphorylation site of the M4 Muscarinic Acetylcholine Receptor. The pS296/pS297-M4 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S296/S297 phosphorylation is a key regulator of M4 desensitization, β-arrestin recruitment and internalization.
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