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Overview
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Threonine311/Serine314 is a major phosphorylation site of the M4 Muscarinic Acetylcholine Receptor. The pT311/pS314-M4 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T311/S314 phosphorylation is a key regulator of M4 desensitization, β-arrestin recruitment and internalization.
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Overview