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Overview
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Serine375 (S375) is the primary phosphorylation site in a hierarchical phosphorylation cascade. The pS375-MOP antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S375 phosphorylation is a key regulator of MOP desensitization, β-arrestin recruitment and internalization. The pS375-MOP antibody can detect phosphorylated MOP in mouse brain in vivo.
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Overview