pT376-MOP ( IHC-grade phospho-µ-Opioid Receptor Polyclonal Antibody )

Overview
- Threonine376 (T376) is a major phosphorylation site of the µ-opioid receptor (MOP). The pT376-MOP antibody detects phosphorylation in response to high-efficacy agonists but to low-efficacy agonists or after PKC activation. T376 phosphorylation is a key regulator of MOP desensitization, β-arrestin recruitment and tolerance. The pT376-MOP antibody can detect phosphorylated MOP in mouse brain in vivo.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  A synthetic phosphopeptide derived from human MOP around the phosphorylation site of Thr376.
  
  Purification
  
  Antigen affinity chromatography
  
  Formulation
  
  Liquid
  
  Storage
  
  Short-term storage at 4°C and long-term storage at -20°C
  
  Antigen
  
  MOP, OPRM1, µ-Opioid Receptor, Mu Receptor (UniProt:P35372 (human), P42866 (mouse), P33535 (rat))
  
  * This product is intended for research use only.

Applications

Application	Dilutions
Immunohistochemistry (IHC)	1:50

Reference
- Fritzwanker S, Nagel F, Kliewer A, Stammer V, Schulz S. In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies. Commun Biol. 2023 Apr 15;6(1):419. doi: 10.1038/s42003-023-04786-2. PMID: 37061609; PMCID: PMC10105690.