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Overview
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Threonine379 (T379) is a major phosphorylation site of the µ-opioid receptor (MOP). The pT379-MOP antibody detects phosphorylation in response to high-efficacy agonists but to low-efficacy agonists or after PKC activation. T379 phosphorylation is a key regulator of MOP desensitization, β-arrestin recruitment and tolerance. The pT379-MOP antibody can detect phosphorylated MOP in mouse brain in vivo.
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- Properties
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Overview