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Overview
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Serine332/Serine333/Serine334 is a major phosphorylation site of the M3 Muscarinic Acetylcholine Receptor. The pS332/pS333/pS334-M3 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S332/S333/S334 phosphorylation is a key regulator of M3 desensitization, β-arrestin recruitment and internalization.
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