Name: Prothionamide
Price: 198.00 USD

- Overview
  - Prothionamide is a an antibacterial agent and thioamide. It is an analog of ethionamide, containing a propyl group instead of an ethyl group at the α position. It is an anti-tuberculosis compound. It has also been tested for leprosy, otherwise known as Hansen's disease. Research into the mechanism of action of this compound can provide insights into designing new compounds that can overcome resistance.
    
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    Background
    
    The precise methanism of action of Prothionamide is unknown. However, using a cell-based activation method, it has been shown that thioamides form covalent adducts with nicotinamide adenine dinucleotide (NAD) and that these adducts are inhibitors of M. tuberculosis and M. leprae InhA. Crystallography can provide the molecular details of target-compound interactions.
- Properties
  - CAS Number
    
    14222-60-7
    
    Molecular Formula
    
    C9H12N2S
    
    Molecular Weight
    
    180.27
    
    Solubility
    
    Soluble in DMSO. Slightly soluble in ethanol, methanol, ether, and chloroform. Practically insoluble in water.
    
    Other Properties
    
    Source: Synthetic
    Purity Level: 99.0 - 101.0%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: It is highly effective against Mycobacteria, including Mycobacterium tuberculosis, M. leprae, and M. avium.