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Overview
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Propanoyl Coenzyme A (Propanoyl-CoA), also known as propionyl-CoA, is a three-carbon thioester derivative of Coenzyme A that plays a crucial role in intermediary metabolism. It is formed during the catabolism of odd-chain fatty acids, certain amino acids (such as valine, isoleucine, and methionine), and cholesterol. Propanoyl-CoA serves as an intermediate in the conversion of propionate to succinyl-CoA, a key metabolite in the tricarboxylic acid (TCA) cycle. This pathway is vital for energy production and the gluconeogenic process, linking lipid and carbohydrate metabolism in cells (Horswill & Escalante-Semerena, 1999; Luo et al., 2016).
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