Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-maleimide | (30,000-5,000Da, LA:GA 50:50)

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-maleimide | (30,000-5,000Da, LA:GA 50:50)

Catalog Number:
PG01436052AKI
Mfr. No.:
AKI-AI110
Price:
$432
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      • Overview
        • Contain chemically active or activatable endgroups for you to graft on to your own polymer or system of choice. Useful for targeted delivery and immunotherapy applications.​ Note for indicated block copolymers "(w:w)" denotes that the ratio shown is based on component weight rather than molar content.

          Please contact us at for specific academic pricing.

      • Properties
        • Categories
          Intermediates
          Alternative Name
          Poly(Lactic-co-glycolic acid)-Poly(ethylene glycol)-maleimide; PLGA-PEG-Mal
          Other Properties
          (Mw ~30,000-5,000Da, LA:GA 50:50)

          * For Research Use Only

      • Applications
        • Application
          Customer endcapping with peptide ligands (must contain free thiol)
      • Reference
        • 2023
          Jung, Sungwook, Moufida Ben Nasr, Baharak Bahmani, Vera Usuelli, Jing Zhao, Gianmarco Sabiu, Andy Joe Seelam et al.. "Nano‐Targeted Delivery of Immune Therapeutics in type 1 Diabetes".Advanced Materials(2023): 2300812.
          Product Usage: Decorated Nanoparticle Shell
          Murar, Madhura, Silvia Pujals, and Lorenzo Albertazzi. "Multivalent effect of peptide functionalized polymeric nanoparticles towards selective prostate cancer targeting".Nanoscale Advances(2023).
          Product Usage: Decorated Nanoparticle Shell

          2022
          Chen, P.M., Katsuyama, E., Satyam, A., Li, H., Rubio, J., Jung, S., Andrzejewski, S., Becherer, J.D., Tsokos, M.G., Abdi, R. and Tsokos, G.C. "CD38 reduces mitochondrial fitness and cytotoxic T cell response against viral infection in lupus patients by suppressing mitophagy".Science Advances8(24), p.eabo4271
          Product Usage: Decorated Nanoparticle Shell
          Granot, Z., Völs, S., Kaisar-Iluz, N., Shaul, M.E., Ryvkin, A., Ashkenazy, H., Yehuda, A., Atamneh, R., Meital, B.D.N., Nadav, M. and Hirsch, S.. "Targeted Nanoparticles Modify Neutrophil Function In Vivo".Frontiers in Immunologyp.5679.
          Product Usage: Decorated Nanoparticle Shell
          Ramôa, António Miguel, Filipa Campos, Luís Moreira, Cátia Teixeira, Victoria Leiro, Paula Gomes, José das Neves, M. Cristina L. Martins, and Cláudia Monteiro. "Antimicrobial peptide-grafted PLGA-PEG nanoparticles to fight bacterial wound infections".Biomaterials Science(2023)
          Product Usage: Decorated Nanoparticle Shell

          2021
          Azevedo, Cláudia Filipa Maia. "New engineered FcRn-targeting nanoplatforms for oral delivery of biopharmaceuticals".Universidade do PortoPhD Thesis
          Product Usage: Decorated Nanoparticle Shell
          Azevedo, Cláudia, Jan Terje Andersen, Giovanni Traverso, and Bruno Sarmento. "The potential of porcine ex vivo platform for intestinal permeability screening of FcRn-targeted drugs".European Journal of Pharmaceutics and Biopharmaceutics(2021)
          Product Usage: Decorated Nanoparticle Shell
          Azevedo, Cláudia, Maria Helena Macedo, Andreia Almeida, Soraia Pinto, Jack JWA van Loon, and Bruno Sarmento. "The effect of hypergravity in intestinal permeability of nanoformulations and molecules".European Journal of Pharmaceutics and Biopharmaceutics2021
          Product Usage: Decorated Nanoparticle Shell
          de Castro, Renata Ribeiro, Flavia Almada do Carmo, Cláudia Martins, Alice Simon, Valeria Pereira de Sousa, Carlos Rangel Rodrigues, Lucio Mendes Cabral, and Bruno Sarmento. "Clofazimine functionalized polymeric nanoparticles for brain delivery in the tuberculosis treatment".International Journal of Pharmaceutics602 (2021): 120655
          Product Usage: Decorated Nanoparticle Shell
          Garizo, Ana Rita, Flávia Castro, Cláudia Martins, Andreia Almeida, Tiago P. Dias, Fábio Fernardes, Cristina C. Barrias, Nuno Bernardes, Arsénio M. Fialho, and Bruno Sarmento. ""p28-functionalized PLGA nanoparticles loaded with gefitinib reduce tumor burden and metastases formation on lung cancer".Journal of Controlled Release(2021)
          Product Usage: Decorated Nanoparticle Shell
          Xie, Shaowei, Wenshe Sun, Chunfu Zhang, Baijun Dong, Jingxing Yang, Mengfei Hou, Liqin Xiong, Biao Cai, Xuesong Liu, and Wei Xue. "Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy".ACS Nano(2021)
          Product Usage: Decorated Nanoparticle Shell

          2020
          Azevedo, Cláudia, Jeannette Nilsen, Algirdas Grevys, Rute Nunes, Jan Terje Andersen, and Bruno Sarmento. "Engineered albumin-functionalized nanoparticles for improved FcRn binding enhance oral delivery of insulin".Journal of Controlled Release(2020)
          Product Usage: Decorated Nanoparticle Shell
          Baião, Ana, Flávia Sousa, Ana Vanessa Oliveira, Carla Oliveira, and Bruno Sarmento. "Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting the CD44v6 receptor in colon cancer cells".Biomaterials Science(2020)
          Product Usage: Decorated Nanoparticle Shell
          Ordikhani, Farideh, Vivek Kasinath, Mayuko Uehara, Aram Akbarzadeh, Osman A. Yilmam, Li Dai, Hamza Aksu et al.. "Selective trafficking of light chain-conjugated nanoparticles to the kidney and renal cell carcinoma".Nano Today35 (2020): 100990
          Product Usage: Decorated Nanoparticle Shell
          Shen, Jing, Wenpeng Cai, Yongfang Ma, Ruyue Xu, Zhen Huo, Li Song, Xinyin Qiu et al. "hGC33-Modified and Sorafenib-Loaded Nanoparticles have a Synergistic Anti-Hepatoma Effect by Inhibiting Wnt Signaling Pathway".Nanoscale Research Letters15, no. 1 (2020): 1-15
          Product Usage: Decorated Nanoparticle Shell

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