PKAkt1/PKBa Recombinant Protein

PKAkt1/PKBa Recombinant Protein

Catalog Number:
P001418438ABE
Mfr. No.:
Abe32-3085; Abe32-3086
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      • Overview
        • Recombinant Human Protein Kinase B is a glycosylated polypeptide having a molecular mass of 59.1 kDa. Recombinant Protein Kinase B is purified by proprietary chromatographic techniques. Akt1, also known as Akt or protein kinaseB (PKB) is an important molecule in mammaliancellular signaling. In humans, there are three genes in the Akt family: Akt1, Akt2, and Akt3. These enzymesare members of the serine/threonine-specific protein kinasefamily (EC2.7.11.1). Akt1 is involved in cellular survival pathways, by inhibiting apoptoticprocesses. Akt1 is also able to induce protein synthesispathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogenein the transforming retrovirus, AKT8.

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      • Properties
        • Protein Name
          RAC-alpha serine/threonine-protein kinase, EC 2.7.11.1, RAC-PK-alpha, Protein kinase B, PKB, C-AKT, AKT1, AKT, RAC, PRKBA, MGC99656, RAC-ALPHA.
          Source
          Sf9 cells
          Type
          Recombinant Proteins
          Purification
          Greater than 90% as determined by SDS-PAGE.
          Formulation
          PKAkt1 1.9mg/ml, in 50mM NaCl, 1mM DTT, 25mM beta glycerophosphate, 50% glycerol, pH 8.5.
          Storage
          Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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