Name: Phospho-Troponin I (Cardiac) (Ser23/24) Antibody
Price: 180.00 USD

Overview
- Sensitivity: Endogenous
  Target name: Phospho-Troponin I (Cardiac) (Ser23/24) antibody
  Area: Metabolism/Cardiovascular
  
  Please contact us at for specific academic pricing.
  
  Background
  
  Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]
Properties
- Host
  
  Rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  Human, Mouse, Rat
  
  Clone
  
  pAb
  
  Immunogen
  
  Synthetic peptide corresponding to residues surrounding Ser23/24 of human Troponin I (Cardiac)
  
  Storage
  
  Store at +4°C for short term storage. Long time storage is recommended at -20°C.
  100mM Tris Glycine, 30% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
  Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
  
  Molecular Weight
  
  28
  
  * For research use only.