Name: Phospho-ERK1+ERK2 (Thr202 / Tyr204) Antibody
Price: 180.00 USD

Overview
- Sensitivity: Endogenous
  Target name: Phospho ERK1+2 (Thr202/Tyr204)
  Area: Signaling
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Properties
- Host
  
  Rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  Human, Mouse, Rat
  
  Clone
  
  pAb
  
  Immunogen
  
  Synthetic peptide corresponding to residues surrounding Thr202 of human ERK
  
  Storage
  
  Store at +4°C for short term storage. Long time storage is recommended at -20°C
  100mM Tris Glycine, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative
  
  Molecular Weight
  
  42, 44
  
  * For research use only.

Applications

Application

WB; IF

Application	Dilutions
Western Blot	1:500–1:1000
Immunofluorescence	1:200–1:500

Application	Species	Publication
WB/ICC/IF	Human	Article URL
WB	Human	Article URL
WB	Rat	Article URL

Reference
- Liang, Chi-Yen et al. "Patchouli alcohol induces G0 /G1 cell cycle arrest and apoptosis in vincristine-resistant non-small cell lung cancer through ROS-mediated DNA damage." Thoracic cancer, 10.1111/1759-7714.14982. 30 May. 2023
  Chang, Kai-Fu et al. "Downregulation of VEGFR2 signaling by cedrol abrogates VEGF‑driven angiogenesis and proliferation of glioblastoma cells through AKT/P70S6K and MAPK/ERK1/2 pathways." Oncology letters vol. 26,2 342. 22 Jun. 2023
  Su, Chin-Ya et al. "Neng-Jing-Huo Essential Oil Blend Inhibits Lipopolysaccharide-Induced Intracellular Reactive Oxygen Species Accumulation, Inflammation, and Apoptosis in Renal Tubular Epithelial Cells." Journal of physiological investigation vol. 68,1 (2025)

Documents

Datasheet

Phospho-ERK1+ERK2 (Thr202 / Tyr204) Antibody

Phospho-ERK1+ERK2 (Thr202 / Tyr204) Antibody

Background

Documents

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