Name: Phenformin HCl
Price: 228.00 USD

- Overview
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    Background
    
    Phenformin HCl is a hydrochloride salt of the biguanidine drug phenformin.Phenformin is the biguanide class that displays anti-diabetic activity.In 5 patients with diabetes mellitus, phenformin reduced the blood glucose values and glycosuria. In 4 of 5 patients, cholesterol and total lipid levels were dropped. Also, Phenformin had no impact on glucose, nor the insulin levels after intravenous glucose loading.
    
    [1]. Geldermans CA, Terpstra J, Krans HM. The effect of phenformin-HCl on patients with diabetes mellitus, studied under strict balance conditions. Diabetologia, 1975, 11(5): 475-482.
- Properties
  - Categories
    
    biguanidine drug with anti-diabetic activity
    
    Alternative Name
    
    1-(diaminomethylidene)-2-(2-phenylethyl)guanidine;hydrochloride
    
    CAS Number
    
    834-28-6
    
    Molecular Formula
    
    C10H16ClN5
    
    Molecular Weight
    
    241.72
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥12.1 mg/mL in DMSO; ≥17.53 mg/mL in EtOH; ≥24.5 mg/mL in H2O with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C1=CC=C(C=C1)CCN=C(N)N=C(N)N.Cl
    
    * For Research Use Only
- Reference
  - 1. Pathria G, Scott DA, et al. "Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival." EMBO J. 2018 Oct 15;37(20). pii:e99735. PMID:30209241