Phellopterin

- Overview
  - Phellopterin is natural product of the coumarin class extracted from Angelica dahurica. Phellopterin exerts anti-inflammatory effects both in vitro and in vivo, and the potential mechanism depends on SIRT1. hellopterin showed therapeutic benefits in the healing process by attenuating chronic inflammation and promoting re-epithelialization, along with SIRT1 upregulation and ICAM-1 downregulation. However, inhibiting SIRT1 reversed its proliferative and anti-inflammatory effects. It can reduce TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.
    
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- Properties
  - Categories
    
    Natural Products
    
    CAS Number
    
    2543-94-4
    
    Molecular Formula
    
    C17H16O5
    
    Molecular Weight
    
    300.31
    
    Purity
    
    ≥98%
    
    Storage
    
    Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
    In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
    
    Shipping
    
    Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
    
    SMILES
    
    O1C([H])=C([H])C2=C(C3C([H])=C([H])C(=O)OC=3C(=C12)OC([H])([H])/C(/[H])=C(\C([H])([H])[H])/C([H])([H])[H])OC([H])([H])[H]
    
    * For research use only

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