PF-8380

PF-8380

Catalog Number:
L002368816APE
Mfr. No.:
APE-A3720
Price:
$212
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      • Overview
        • Please contact us at for specific academic pricing.

          Background

          PF-8380 is a specific and potent inhibitor of Autotaxin (ATX) with an IC50 value of 2.8 nM [1].
          Autotaxin (ATX) is a secreted enzyme having lysophospholipase D activity

      • Properties
        • Alternative Name
          PF 8380;PF8380; 3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate
          CAS Number
          1144035-53-9
          Molecular Formula
          C22H21Cl2N3O5
          Molecular Weight
          478.33
          Appearance
          A solid
          Purity
          99.51%
          Solubility
          insoluble in H2O; insoluble in EtOH; ≥20.9 mg/mL in DMSO
          Storage
          Store at -20°C

          * For Research Use Only

      • Reference
        • 1. Yaya Wang, Jie Zhang, et al. "The LPA-CDK5-Tau Pathway Mediates Neuronal Injury in an In Vitro Model of Ischemia-Reperfusion Insult." BMC Neurol. 2022 May 2;22(1):166. PMID:35501719
          2. Wang C, Zhang J, et al. "Lysophosphatidic acid induces neuronal cell death via activation of asparagine endopeptidase in cerebral ischemia-reperfusion injury." Exp Neurol. 2018 Aug;306:1-9. PMID:29673933

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