Name: Perifosine
Price: 145.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Perifosine is an inhibitor of Akt [1].
    Perifosine is a synthetic antitumor alkylphospholipid. It induces cell apoptosis through inhibiting the activity of Akt. Perifosine shows antitumor activity in various cell lines including NSCLC, MM, epithelial carcinoma, prostate carcinoma and leukemia cells. In H460 cells, perifosine decreased cell survival and induced apoptosis with IC50 values of 1μM and 10 μM, respectively. The treatment of perifosine was also found to induce cleavage of caspase-8, caspase-9, caspase-3 and PARP in this cell line. In MM.1S cells, perifosine induced sub-G1 phase population increase from 15% to 57% at 10 μM and induced cleavage of caspase-8, caspase-9 and PARP in a dose-dependent manner. In mice inoculated with MM.1S cells, oral administration of perifosine significantly reduced MM tumor growth and increased survival [1, 2].
    
    [1] Elrod H A, Lin Y D, Yue P, et al. The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway. Molecular cancer therapeutics, 2007, 6(7): 2029-2038.
    [2] Hideshima T, Catley L, Yasui H, et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood, 2006, 107(10): 4053-4062.
- Properties
  - Alternative Name
    
    NSC639966;KRX-0401;KRX0401;D-21266;D21266; (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate
    
    CAS Number
    
    157716-52-4
    
    Molecular Formula
    
    C25H52NO4P
    
    Molecular Weight
    
    461.67
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in DMSO; ≥5.55 mg/mL in EtOH with ultrasonic; ≥5.94 mg/mL in H2O with ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Jialin He, Jianyang Liu, et al. "OM-MSCs Alleviate the Golgi Apparatus Stress Response following Cerebral Ischemia/Reperfusion Injury via the PEDF-PI3K/Akt/mTOR Signaling Pathway." Oxid Med Cell Longev. 2021 Nov 13;2021:4805040. PMID:34815829
    2. Zi-Yan Yang, Liu Yang, et al. "An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway." Biol Open. 2020 Jan 24;9(1):bio047662. PMID:31980423
    3. Chen H, Wang X, et al. "AKT and its related molecular feature in aged mice skin." PLoS One. 2017 Jun 7;12(6):e0178969. PMID:28591208

Perifosine

Perifosine

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