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Overview
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This antibody reacts with the CD98 antigen, which is broadly expressed on peripheral blood lymphocytes, monocytes and granulocytes (low) .It is also expressed on non-hematopoietic cells. Reports suggest that CD98 may be involved in the regulation of cellular activation. CD98 is up-regulated on leukocytes and in inflammatory lesions, and strongly expressed by neoplastic cells. However, expression is not hematopoietic specific. CD98 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also it is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas, in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1.
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