PE/AF594 Anti-Human CD45 Antibody

PE/AF594 Anti-Human CD45 Antibody

Catalog Number:
A001510378RED
Mfr. No.:
RD30312F
Price:
$209
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      • Overview
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          Background

          CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.

      • Properties
        • Host
          mouse
          Antibody Type
          monoclonal
          Isotype
          IgG1 kappa
          Reactivity
          human
          Conjugate
          PE/AF594
          Formulation
          PBS with 0.05% Proclin300, 1% BSA
          Storage
          Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
          Antigen
          Receptor-type tyrosine-protein phosphatase C, Ptprc, L-CA, Ly-5, T200, CD45 (Gene ID:5788; UniProt:P08575)

          * For reference only.

      • Applications
        • Application
          FCM

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