Name: PD-1/PD-L1 inhibitor 1
Price: 265.00 USD

- Overview
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    Background
    
    IC50: 0.006-0.10 μMPD-1/PD-L1 inhibitor 1 is a PD-1/PD-L1 interaction inhibitor.Plenty of studies show that blocking the PD-1/PD-Ll interactions can lead to the restorage and augment of T cell activation in many systems. In preclinical animal models, it has been found that blocking the PD-1/PD-Ll pathway by monoclonal antibodies can enhance the immune response and result in tumor shrinkage or control of virus infection. Recent clinical studies have shown that the therapies with a monoclonal antibody to PD-Ll can give benefits to patients with advanced cancer. In vitro: PD-1/PD-L1 inhibitor 1 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (PD-1) with its ligand protein (PD-L1). PD-1/PD-L1 inhibitor 1 was also found to act as an immunomodulator. In preclinical studies, PD-1/PD-L1 inhibitor 1 was able to block PD-1/PD-Ll interactions with an IC50 value between 6 and 100 nM, which was measured by a homogenous time-resolved fluorescence (HTRF) binding assay. Thus, PD-1/PD-L1 inhibitor 1 might potentially be used for the treatment of cancer as well as infectious diseases, such as hepatitis C [1]. In vivo: So far, there is no animal in vivo data reported for PD-1/PD-L1 inhibitor 1. Clinical trial: Up to now, PD-1/PD-L1 inhibitor 1 is still in the preclinical development stage.
- Properties
  - Alternative Name
    
    (S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid
    
    CAS Number
    
    1675201-83-8
    
    Molecular Formula
    
    C29H33NO5
    
    Molecular Weight
    
    475.58
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥5.98 mg/mL in DMSO with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

PD-1/PD-L1 inhibitor 1

PD-1/PD-L1 inhibitor 1

Background

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