Name: Paxilline
Price: 289.00 USD

- Overview
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    Background
    
    Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa, KCa1.1) channels[1,2]. It also enhances the binding of charybdotoxin, a peptidyl neurotoxin, to BKCa channels. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (IC50 = 5 - 50 μM)[3].
    
    [1]. Sanchez M, McManus O B. Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology, 1996, 35(7): 963-968.
    [2]. Li G, Cheung D W. Effects of paxilline on K+ channels in rat mesenteric arterial cells. European Journal of Pharmacology , 1999, 372: 103-107.
    [3]. Knaus H G, McManus O B, Lee S H, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry, 1994, 33(19): 5819-5828.
- Properties
  - Categories
    
    high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels blocker
    
    Alternative Name
    
    (2R,4bS,6aR,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one
    
    CAS Number
    
    57186-25-1
    
    Molecular Formula
    
    C27H33NO4
    
    Molecular Weight
    
    435.56
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Desiccate at -20°C
    
    SMILES
    
    O[[email protected]]1(C2=C3)[[email protected]@](CC[[email protected]@H]2O[[email protected]](C(C)(C)O)C3=O)(C)[[email protected]](C(NC4=CC=CC=C54)=C5C6)(C)[[email protected]@H]6CC1
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Paxilline

Paxilline

Background

Documents

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