Name: Pan-Akt Polyclonal Antibody (1 mg/mL) for WB, IHC-P, IF, ELISA
Price: 253.00 USD

Overview
- Calculated MW: 56 kDa
  Observed MW: 50 kDa
  
  Please contact us at for specific academic pricing.
  
  Background
  
  Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Synthesized peptide derived from human Akt around the non-phosphorylation site of Tyr315.
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  1 mg/mL
  
  Antigen
  
  AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT2, RAC-beta serine/threonine-protein kinase, Protein kinase Akt-2, Protein kinase B (UniProt:P31749,P31751,Q9Y243)
  
  * For reference only.

Applications

Application

WB; IHC-P; IF; ELISA

Application	Dilutions
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:50-1:200
ELISA	1:40000

Pan-Akt Polyclonal Antibody (1 mg/mL) for WB, IHC-P, IF, ELISA

Pan-Akt Polyclonal Antibody (1 mg/mL) for WB, IHC-P, IF, ELISA

Background

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