Name: OP-145
Price: 331.00 USD

- Overview
  - Antimicrobial peptide derived from LL-37.
    OP-145 is a synthetic antimicrobial peptide derived from amino acid sequence 13 36 of human cathelicidin LL-37, further modified to favour the formation of an amphipathic helix. To improve stability against proteolytic degradation, the N-terminus is acetylated and the C-terminus amidated. OP-145 is a potent antibacterial, only lytic to human cells at high concentrations, and shows significant activity against nine methicillin-resistant Staphylococcus aureus (MRSA) strains, reducing their growth and biofilm formation. OP-145 is safe and effective against chronic middle ear infection (otitis media) in humans, and when formulated in poly(lactic-co-glycolic acid) (PLGA) microspheres, OP-145 exerts strong anti-biofilm effects on clinical isolated pathogens and exerts powerful anti-infection effects in vivo.
    
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- Properties
  - Categories
    
    Antimicrobial Peptides
    
    Alternative Name
    
    P60.4Ac
    
    Molecular Formula
    
    C142H246N46O31
    
    Molecular Weight
    
    3093.77
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: Ac-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Glu-Arg-Ile-Lys-Arg-Phe-Leu-Arg-Glu-Leu-Val-Arg-Pro-Leu-Arg-NH2,Ac-IGKEFKRIVERIKRFLRELVRPLR-NH2
    Modification: N terminal acetyl, C terminal amide
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

OP-145

OP-145

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