Name: OG-L002 HCl
Price: 260.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    OG-L002 is a specific and potent inhibitor of lysine (K)-specific demethylase 1A (LSD1) with IC50 value of 20 nM [1].LSD1 is a flavin-dependent monoamine oxidase, which can demethylate lysines. LSD1 plays critical roles in oocyte growth, embryogenesis and tissue-specific differentiation [2].OG-L002 potently inhibited HSV IE gene expression in both HFF and HeLa cells with IC50 of ~3 μM and ~10 μM, respectively. OG-L002 treatment can potently reduce production of progeny virus (~100-fold) with no significant toxicity in HeLa or HFF cells. In chromatin immunoprecipitation assays, OG-L002 increased the levels of total histone H3K9-me2 and H3 (20- to 30-fold) associated with viral IE promoters, which resulted in decreased viral IE gene expression. In addition, OG-L002 also repressed the expression of adenovirus E1A gene and hCMV IE genes [1]. In a mouse model, OG-L002 repressed primary HSV infection in a dose-dependent manner. Moreover, OG-L002 plays an important role in the viral latency-reactivation cycle in a mouse ganglion explant model [1].
    
    [1]. Liang Y, Quenelle D, Kristie TM, et al. A Novel Selective LSD1/KDM1A Inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. mBio, 2013, 4(1), e00558-12.
    [2]. Pedersen MT, Helin K. Histone demethylases in development and disease. Trends in Cell Biology, 2010, 20 (11): 662-71.
- Properties
  - Alternative Name
    
    4'-((1R,2S)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol hydrochloride
    
    CAS Number
    
    1357298-75-9
    
    Molecular Formula
    
    C15H16ClNO
    
    Molecular Weight
    
    261.75
    
    Appearance
    
    A solid
    
    Purity
    
    99.37%
    
    Solubility
    
    ≥26.2 mg/mL in DMSO; insoluble in H2O; ≥26.05 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

OG-L002 HCl

OG-L002 HCl

Background

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