Octyl b-D-thioglucopyranoside

- Overview
  - Octyl β-D-thioglucopyranoside is an alkylglycoside non-ionic detergent used for cell lysis and membrane protein isolation. As it is uncharged, it is unlikely to cause protein denaturation or refolding issues, allowing for the isolation of intact macromolecular complexes without affecting protein-protein interactions. Octyl β-D-thioglucopyranoside is also known as n-Octyl b-D-thioglucoside or OTG and has an aggregation number of 189. It is dialyzable from membrane protein preparations and has a Critical Micelle Concentration (CMC) of 9mM. Octyl β-D-thioglucopyranoside has similar uses and properties to that of another frequently used surfactant, n-Octyl-beta-D-glucopyranoside. However, Octyl β-D-thioglucopyranoside is more stable and is unaffected by beta-glucosidase enzyme due to its thioether linkage.
    
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- Properties
  - Alternative Name
    
    n-Octyl b-D-thioglucoside;OTG
    
    CAS Number
    
    85618-21-9
    
    Molecular Formula
    
    C14H28O5S
    
    Molecular Weight
    
    308.44 g/mol
    
    MDL Number
    
    MFCD00012189
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Saito et al (1985) Synthesis of Alkyl-β-D-thioglucopyranosides, a Series of New Nonionic Detergents. Chemical and Pharmaceutical Bulletin 33(3):503-508.
    Saito et al (1984) Characteristics of n-octyl β-d-thioglucopyranoside, a new non-ionic detergent useful for membrane biochemistry. Biochemical Journal 222: 829-832.
    Wenk et al (1997). Interaction of octyl-beta-thioglucopyranoside with lipid membranes. Biophysical journal 73(5), 2565–2574.

MSDS

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Specification

Octyl b-D-thioglucopyranoside

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