O-Methylviridicatin

- Overview
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    Background
    
    IC50: 2.5 μM: inhibits virus production in OM-10.1 cells (HL-60 promyelocytes infected with HIV-1) treated with TNF-α.5 μM: blocks activation of the HIV long terminal repeat by TNF-α in HeLa cellsO-Methylviridicatin, a natural derivative of the alkaloid mycotoxin viridicatin, is produced by several species in the genus, Penicillium. It is demonstrated that O-Methylviridicatin, as an inhibitor, blocks the tumor necrosis factor alpha (TNFα)-induced replication of human immunodeficiency virus (HIV). TNFα increases the binding of the cellular transcription factor NF-κB to the HIV long terminal repeat (LTR), which directly triggers transcription of the latent provirus.In vitro: O-Methylviridicatin had an inhibitory effect on the TNFα-triggered replication of HIV LTR in HeLa cells. In addition, O-Methylviridicatin dose-dependently dampened virus production in the OM-10.1 cell line, which was measured by the output of p24 core antigen into the culture medium. It was demonstrated that the suppressive effect of O-Methylviridicatin was not reversed even if the concentration of TNFα was increased 10-fold [1]. In vivo: Up to now, in vitro study of O-Methylviridicatin is still in the development stage.
    
    [1]. Heguy, A., Cai, P., Meyn, P., Houck, D., Russo, S., & Michitsch, R. et al. Isolation and Characterization of the Fungal Metabolite 3-O-Methylviridicatin as an Inhibitor of Tumour Necrosis Factor-Induced Human Immunodeficiency Virus Replication. Antiviral Chemistry and Chemotherapy. 1998; 9(2): 149-155.
- Properties
  - Categories
    
    blocks activation of the HIV long terminal repeat by TNF-α
    
    Alternative Name
    
    AIDS-089094,3-methoxy-4-phenyl-Carbostyril,Viridicatin methyl ester; 3-methoxy-4-phenyl-2(1H)-quinolinone
    
    CAS Number
    
    6152-57-4
    
    Molecular Formula
    
    C16H13NO2
    
    Molecular Weight
    
    251.3
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C1NC2=C(C=CC=C2)C(C3=CC=CC=C3)=C1OC
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

O-Methylviridicatin

Background

Documents

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