Name: NSC 3852
Price: 196.00 USD

- Overview
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    Background
    
    NSC 3852 is a potent inhibitor of histone deacetylase [1].
    Histone deacetylases (HADC) are a series of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone and make the histones to wrap the DNA more tightly, which prevent transcription.
    In MCF-7 human breast cancer cells, NSC 3852 induced the formation of the DMPO-OH adduct, which was catalyzed by superoxide dismutase. The result suggested that NSC 3852 induced generation of superoxide and reactive oxygen species (ROS), which produced DNA damage and induced apoptosis. Also, NSC 3852 resulted in cells accumulation in G0, hypophosphorylated retinoblastoma protein(Rb) and reduced E2F1 and Myc protein [1]. In HS68 cell, NSC 3852 inhibited Toxoplasma gondii tachyzoite propagation with EC50 value of 78.6 nM. Also, in human red blood cells, NSC 3852 inhibited Plasmodium falciparum growth with EC50 value of 1.3 μM. NSC 3852 inhibited Toxoplasma gondii tachyzoite propagation by involving redox reactions [2].
    
    [1]. Martirosyan A, Leonard S, Shi X, et al. Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells. J Pharmacol Exp Ther, 2006, 317(2): 546-552.
    [2]. Strobl JS, Seibert CW, Li Y, et al. Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agent. J Parasitol, 2009, 95(1): 215-223.
- Properties
  - Alternative Name
    
    5-nitrosoquinolin-8-ol
    
    CAS Number
    
    3565-26-2
    
    Molecular Formula
    
    C9H6N2O2
    
    Molecular Weight
    
    174.16
    
    Appearance
    
    A solid
    
    Purity
    
    98.87%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥7.35 mg/mL in DMSO
    
    Storage
    
    Store at RT
    
    * For Research Use Only

NSC 3852

NSC 3852

Background

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