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Overview
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Calculated MW: 31 kDa/101 kDa/107 kDa/113 kDa/114 kDa/120 kDa
Observed MW: 120 kDaPlease contact us at for specific academic pricing.
Background
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.
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