Nitrocefin

- Overview
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    Background
    
    Nitrocefin is a chromogenic cephalosporin substrate which is used for detection of β-lactamases. β-lactamases are enzymes produced by various microbes that mediate resistance to β-lactam antibiotics such as penicillins and cephamycins. Comparing to other methods for β-lactamases detection, nitrocefin is more sensitive while using few materials and inexpensive equipment. The color change by nitrocefin can be followed quantitatively by measuring changes in absorption between 380 to 500 nm region[1].
    
    Reference:[1] O'Callaghan, Cynthia H et al. Novel Method for Detection of B-Lactamases by Using a Chromogenic Cephalosporin Substrate. Antimicrobial Agents and Chemotherapy. 1972 Apr; 1(4):283-288.
- Properties
  - Categories
    
    Used for detection of β-lactamases
    
    Alternative Name
    
    (6R,7R)-3-((E)-2,4-dinitrostyryl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
    
    CAS Number
    
    41906-86-9
    
    Molecular Formula
    
    C21H16N4O8S2
    
    Molecular Weight
    
    516.50
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥20.24 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    [H][[email protected]]1([[email protected]@H]2NC(CC3=CC=CS3)=O)SCC(/C=C/C4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)=C(C(O)=O)N1C2=O
    
    * For Research Use Only
- Reference
  - 1. Liu X, Ma L, et al. "Synergistic antibacterial mechanism of Bi(2)Te(3) nanoparticles combined with the ineffective β-lactam antibiotic cefotaxime against methicillin-resistant Staphylococcus aureus." J Inorg Biochem. 2019 Jul;196:110687." PMID:31004991

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Nitrocefin

Background

Documents

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