Name: NG,NG-dimethyl-L-Arginine (hydrochloride)
Price: 290.00 USD

- Overview
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    Background
    
    NG,NG-dimethyl-L-Arginine is an endogenous nitric oxide synthase inhibitor.Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence.In vitro: NG,NG-dimethyl-L-Arginine (ADMA) was found to be able to inhibit macrophage and vascular NO synthase. When added to a cytosolic preparation of macrophage NO synthase, ADMA could cause dose-dependent inhibition of NO formation. In the presence of added arginine, ADMA could inhibited NO synthesis and the inhibitory effects of ADMA were prevented by addition of L-arginine so that the rate of NO synthesis did not significantly differ from control values [1].In vivo: Animal study showed that the injection of 1-30 mg/kg ADMA into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. Moreover, during continuous infusion of ADMA, which caused plasma ADMA concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].Clinical trial: Local infusion of ADMA into the brachial artery of healthy volunteers caused a dose-dependent fall in forearm blood-flow. Infusion of ADMA for 5 min resulted in a fall in forearm blood-flow in 5 subjects, and the effects of this ADMA dose were significantly attenuated by infusion of L-arginine [1].
- Properties
  - Alternative Name
    
    ADMA; N5-[(dimethylamino)iminomethyl]-L-ornithine, dihydrochloride
    
    CAS Number
    
    220805-22-1
    
    Molecular Formula
    
    C8H18N4O2·2HCl
    
    Molecular Weight
    
    275.2
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥11.5 mg/mL in EtOH; ≥14.9 mg/mL in H2O; ≥7.96 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Ziang Xie, Lei Hou, et al. "Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation." Nat Commun. 2022 Jan 10;13(1):50. PMID:35013196
    2. Ming Wu, Meijie Yuan, et al. "Renal asymmetric dimethylarginine inhibits fibrosis." FEBS Open Bio. 2020 Oct;10(10):2003-2009. PMID:32794631
    3. Wu M, Lin P, et al. "Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys." FASEB J. 2019 Jun;33(6):6948-6956. PMID:30840839

NG,NG-dimethyl-L-Arginine (hydrochloride)

NG,NG-dimethyl-L-Arginine (hydrochloride)

Background

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