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Overview
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Please contact us at for specific academic pricing.
Background
NBQX disodium salt is a potent, highly selective and competitive antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors (AMPARs). The AMPAR is one type of ionotropic glutamate receptors, well known to be involved in various neurological disorders such as Alzheimer disease, schizophrenia, and epilepsy, by mediating long-term potentiation, excitotoxicity, or both. Inhibition of AMPARs with NBQX shows neuroprotective and anticonvulsant activity.
1. Fukushima K, Tabata Y, Imaizumi Y, et al. Characterization of human hippocampal neural stem/progenitor cells and their application to physiologically relevant assays for multiple ionotropic glutamate receptors. Journal of Biomolecular Screening, 2014, 19(8): 1174-1184.
2. Chen W, Li YS, Gao J, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One, 2016, 11(11): e0166672.
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