Nadifloxacin

- Overview
  - Nadifloxacin is a fluorinated fluoroquinolone antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, especially Propionibacterium acnes. It also shows antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Nadifloxacin is capable of treating green nail syndrome caused by Pseudomonas aeruginosa.
    
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    Background
    
    Nadifloxacin inhibits Topo II (DNA gyrase) in Gram-negative bacteria, and Topo IV in Gram-positive bacteria, which both function to relax positive supercoils prior to DNA replication, thus inhibiting bacterial multiplication.
- Properties
  - CAS Number
    
    124858-35-1
    
    Molecular Formula
    
    C19H21FN2O4
    
    Molecular Weight
    
    360.379 g/mol
    
    Appearance
    
    Off white to pale yellow crystalline powder
    
    Solubility
    
    DMSO (20 mg/ml) @ 25°C) water (<1 mg/ml @ 25°C), ethanol (<1 mg/ml @ 25°C).
    
    Other Properties
    
    Source: Synthetic
    Purity Level: ≥99.5%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: broad-spectrum activity against Gram-positive and Gram-negative bacteria.