N-Oxalylglycine

- Overview
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    Background
    
    IC50: 250 μM: inhibits α-ketoglutarate-dependent enzyme jumonji domain-containing protein 2 (JMJD2) A.IC50: 500 μM: blocks α-ketoglutarate-dependent enzyme JMJD2C.IC50: 24 μM: dampens α-ketoglutarate-dependent enzyme JMJD2E.IC50: 2.1 μM: suppresses the prolyl hydroxylase domain-containing proteins PHD1.IC50: 5.6 μM: depresses the prolyl hydroxylase domain-containing proteins PHD2.N-Oxalylglycine, as known as NOG, is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes which include JMJD2A, JMJD2C, and JMJD2E. NOG also blocks the prolyl hydroxylase domain-containing proteins PHD1 and PHD2. Demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 can be catalyzed by JMJD2 subfamily of histone demethylases. Since histone demethylases are related to certain diseases, including cancer, selective inhibitors functions as anticancer agents and potential tools for clarifying the biological functions of JMJDs.In vitro: NOG was identified as a natural product and presented in plants, including Rheum rhabarbarum (rhubarb) and Spinach oleracea (spinach) leaves. However, there was no NOG observed human embryonic kidney cells (HEK 293T) or Escherchia coli. NOG regulated gene expression via blocking 2-Oxoglutarate-dependent oxygenases [1].In vivo: Up to now, in vivo study of NOG is still in the development stage.
- Properties
  - Alternative Name
    
    NOG; N-(carboxycarbonyl)-glycine
    
    CAS Number
    
    5262-39-5
    
    Molecular Formula
    
    C4H5NO5
    
    Molecular Weight
    
    147.1
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; ≥3.82 mg/mL in DMSO with ultrasonic; ≥9.55 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

N-Oxalylglycine

Background

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