N-Benzylpalmitamide

- Overview
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    Background
    
    N-Benzylpalmitamide is an inhibitor of fatty acid amide hydrolase (FAAH) [1]. The fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. The FAAH is involved in degrading the fatty acid amide family of endogenous signaling lipids, including the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. FAAH belongs to is a member of amidase signature (AS) family. The FAAH integrates into cell membranes and terminates fatty acid amide signaling in vivo [2]. Genetic mutations in FAAH may constitute important risk factors for problem drug use and support a potential link between functional abnormalities in the endogenous cannabinoid system and drug abuse and dependence [3]. N-Benzylpalmitamide was a long-chain fatty acid amide isolated from the maca (L. meyenii) plant and was structurally related to cannabinoids. N-Benzylpalmitamide was a moderate inhibitor of FAAH and inhibited 44% activity of FAAH at 500 μM [1].
    
    [1] Wu H, Kelley C J, Pino-Figueroa A, et al. Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition[J]. Bioorganic & medicinal chemistry, 2013, 21(17): 5188-5197.
    [2] Deutsch D G, Ueda N, Yamamoto S. The fatty acid amide hydrolase (FAAH)[J]. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002, 66(2): 201-210.
    [3] Sipe J C, Chiang K, Gerber A L, et al. A missense mutation in human fatty acid amide hydrolase associated with problem drug use[J]. Proceedings of the National Academy of Sciences, 2002, 99(12): 8394-8399.
- Properties
  - Alternative Name
    
    N-Benzylhexadecanamide; N-(phenylmethyl)-hexadecanamide
    
    CAS Number
    
    74058-71-2
    
    Molecular Formula
    
    C23H39NO
    
    Molecular Weight
    
    345.6
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤2mg/ml in organic solvent ethanol
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

N-Benzylpalmitamide

Background

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