N-(3-hydroxyphenyl)-Arachidonoyl amide

- Overview
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    Background
    
    IC50: 2 μM N-(3-hydroxyphenyl) -Arachidonoyl amide, also known as 3-HPAA, is an analog of AM404 (N-(4-hydroxyphenyl)-arachidonoyl amide), a selective inhibitor of carrier-mediated transport of arachidonoyl ethanolamide. 3-HPAA, metabolized by both cyclooxygenase (COX) -1 and COX-2, is an irreversible and selective inhibitor of COX-2 with an IC50 value of 2 M. 3-HPAA can be efficiently oxygenated to prostaglandin and hydroxyeicosatetraenoate products by prostaglandin endoperoxide synthase (PGHS) -2. It appears that 3-HPAA can be converted by PGHS-1 in a similar manner. COX enzymes play elaborate roles in human physiology and pathology, involving neuronal, immune, renal, cardiovascular, gastrointestinal, and reproductive systems. COX enzymes are blocked by aspirin and a wide variety of other non-steroidal anti-inflammatory drugs, which makes them clinically important [1]. COX-2, overexpressed in cancer cells, promotes tumorigenesis and induces neo-angiogenesis. Additionally, it plays an important role in inflammation and pyrexia.In vitro: Up to now, in vitro study of 3-HPAA is still in the development stage.In vivo: Up to now, in vivo study of 3-HPAA is still in the development stage.
- Properties
  - Alternative Name
    
    3-HPAA; N-(3-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
    
    CAS Number
    
    183718-75-4
    
    Molecular Formula
    
    C26H37NO2
    
    Molecular Weight
    
    395.6
    
    Appearance
    
    A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

N-(3-hydroxyphenyl)-Arachidonoyl amide

N-(3-hydroxyphenyl)-Arachidonoyl amide

Background

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