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Overview
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Calculated MW: 62kDa
Observed MW: 70kDaPlease contact us at for specific academic pricing.
Background
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1,IRAK2,IRF7 and TRAF6,leading to NF-kappa-B activation,cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway.
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