Name: MUC1 Antibody (extracellular)
Price: 180.00 USD

Overview
- Sensitivity: Endogenous
  Target name: MUC1 / Mucin 1 / CD227
  Area: Cancer Biomarker
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Properties
- Host
  
  Rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  Human
  
  Clone
  
  pAb
  
  Immunogen
  
  Synthetic peptide/MUC1 extracellular domain
  
  Storage
  
  Store at +4°C for short term storage. Long time storage is recommended at -20°C
  100mM Tris Glycine, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
  Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
  
  Molecular Weight
  
  200-300
  
  * For research use only.