Moxidectin

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Moxidectin is a macrocyclic lactone anthelmintic drug used to control or prevent parasitic worms. Its principal use is veterinary, in animals ranging from cats and dogs to horses and cattle. Moxidectin-susceptible parasites include Strongylus vulgaris in horses and Ostertagia ostertagi in cattle. In 2018, moxidectin was approved by FDA for treating onchocerciasis (river-blindness) caused by the parasitic worm Onchocerca volvulus.
    
    1. Rolfe PF, Dawson KL, Holm-Martin M. Efficacy of moxidectin and other anthelmintics against small strongyles in horses. Australian Veterinary Journal, 1998, 76(5): 332-334.
    2. Hubert J, Kerboeuf D, Cardinaud B, et al. Persistent efficacy of topical moxidectin against Dictyocaulus viviparus and Ostertagia ostertagi. Veterinary Parasitology, 1997, 68(1-2): 187-190.
    3. Awadzi K, Opoku NO, Attah SK, et al. A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin in Onchocerca volvulus infection. PLOS Neglected Tropical Diseases, 2014, 8(6): e2953.
- Properties
  - Categories
    
    An anthelmintic drug
    
    CAS Number
    
    113507-06-5
    
    Molecular Formula
    
    C37H53NO8
    
    Molecular Weight
    
    639.82
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥128 mg/mL in EtOH; ≥129.4 mg/mL in DMSO; ≥3.27 mg/mL in H2O with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(/C([H])=C([[email protected]](O1)([H])[[email protected]@](/C(C[[email protected]@]21C[[email protected]](O3)([H])C[[email protected]@](O2)([H])C/C([H])=C(C[[email protected]@](/C([H])=C([H])/C([H])=C([[email protected]@]45O)\CO[[email protected]]5([H])[[email protected]@](O)([H])C(C)=C[[email protected]@]4([H])C3=O)([H])C)\C)=N\OC)([H])C)\C)C
    
    * For Research Use Only