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Overview
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Mouse TNF-alpha Recombinant Protein (Animal Free) Lyophilized from Innovative Research has been recombinantly produced in E. coli. This is a Lyophilized protein buffered in with a purity of ? 98% by SDS-PAGE gel and HPLC analyses.
Please contact us at for specific academic pricing.
Background
TNF-? is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-? is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-? also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-? demonstrate significant cross-species reactivity. TNF-? exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-? transmembrane protein is proteolitically cleaved to yield a soluble, biologically active, 17 kDa TNF-?, which forms a non-covalently linked homotrimer in solution. Recombinant Murine TNF-? is a soluble 157 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
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- Properties
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