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Overview
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Predicted MW: Dimer, 9.4 / 18.9 kDa (89 / 178 aa). Resistin-like molecule-gamma (RELM-gamma ) is a member of the RELM family of secreted proteins containing C-terminal cysteines. The RELM family consists of Resistin (FIZZ3), RELM-alpha (FIZZ1), RELM-beta (FIZZ2), and RELM-gamma (FIZZ4). RELM-gamma is secreted by peripheral blood granulocytes, bone marrow, spleen, intestine, and lung. RELM-gamma functions to promote and regulate promyelocytic differentiation, in addition to regulating nutrient-associated insulin sensitivity in the intestinal tract. Rodents secrete all four RELM family members, whereas Resistin and RELM-beta are the only RELM family members found in humans.
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Overview