Name: Mouse anti-ERK 1/2 Monoclonal Antibody
Price: 253.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG
    
    Reactivity
    
    human; mouse; rat
    
    Immunogen
    
    Synthetic Peptide of ERK1/2
    
    Purification
    
    Protein A purification
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
    
    Storage
    
    Store at -20°C. Avoid repeated freeze / thaw cycles.
    
    Concentration
    
    1mg/mL
    
    Antigen
    
    MAPK3; ERK1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p (Gene ID:5594, 5595; UniProt:P27361, P28482)
    
    * For research use only.
- Applications
  - Application
    
    WB; IHC (paraffin)