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MMT-deoxy Guanosine (n-tBPAC) p-methoxy phosphoramidite

MMT-deoxy Guanosine (n-tBPAC) p-methoxy phosphoramidite

Catalog Number:
NAS1055781CHE
Mfr. No.:
ANP-5537
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      • Overview

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      • Properties
        • Categories
          P-Methoxy deoxy Amidites, Labile Protection
          Molecular Formula
          C49H59N6O8P
          Molecular Weight
          891.000
          Shipping
          This material is sensitive to heat and moisture. It requires the fastest shipment possible.
      • Applications
        • Application Description
          RNA Methyl Phosphoramidites, Labile Protection

          Methyl phosphate can be also used for aminoalkyl phosphoramidate oligonucleotide modification that can be introduced post-synthetic modification. Similar pathway for post syn­thetic labeling was applied using H-phosphonate strategy.

          Deprotection Conditions:

          For natural phospodiester: use thiophenol solution (Catalog # RN-1465) to thoroughly remove the P-Methoxy groups prior to ammonia base deprotection.
          In the anti-sense study, the neutral phosphate triester backbone displayed high nuclease resistance and improved cellular uptake.
          For P-Methoxy phospodiester oligonucleotides: use PAC protected methyl phosphoramidites in combination with our ammonia free deprotection solution.

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