MMT-2'-tBDSilyl Adenosine (n-PAC) CED phosphoramidite

MMT-2'-tBDSilyl Adenosine (n-PAC) CED phosphoramidite

Catalog Number:
NAS1056091CHE
Mfr. No.:
ANP-6678
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      • Overview

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      • Properties
        • Categories
          5'-MMT protected RNA Amidites
          Molecular Formula
          C53H66N7O8PSi
          Molecular Weight
          988.190
          Shipping
          This material is sensitive to heat and moisture. It requires the fastest shipment possible.
      • Applications
        • Application Description
          Advantages and Application of 5’ -MMTr in Purine Bases for Oligo Synthesis:

          Use of more potent activator such as 5-(Benzylmercapto)-1H-tetrazole (BTT, pKa=4.08),1 5-Ethylthiotetrazole (ETT, pKa= 4.28),1 which are more acidic in nature compared to 1-H-Tetrazole (pKa= 4.89)1, might lead to the removal of the DMTr group from purine bases during the coupling step of oligo synthesis, thereby causing undesired M+1 oligo growth.
          Since purine bases, A & G, cleave at the 5’-DMTr at a much higher rate than 5’-MMTr, the 5’-MMTr protected nucleoside phosphoramidites is pre­ferred; thus offering a minimal level of M+1 impurities.

          References:

          1) Welz, R.; Muller, S. Tet. Lett. 2002, 43, 795-797.

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