Name: MMP 14 (MT1-MMP) prodomain, catalytic domain, and hemopexin domain, His-tagged
Price: 729.00 USD

- Overview
  - Recombinant soluble pro-MT1-MMP is produced as a periplasmic protein in E. coli. The protein contains prodomain, catalytic domain and hemopexin domain of MT1-MMP. Investigation of MT1-MMP; Generation of active MT1-MMP for progelatinase A activation; Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard.
    
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- Properties
  - Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    More than 80% of total protein
    
    Formulation
    
    Recombinant pro-MT1-MMP is solubilized in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl₂.
    
    Storage
    
    Recombinant pro-MT1-MMP is stable until the expiry date given on the label if stored at -70 °C. The proenzyme can be kept at -20 °C for several weeks. Repeated freezing and thawing should be avoided.
    
    Molecular Weight
    
    58.2 kDa
    
    * For Research Use Only
- Applications
  - Application Description
    
    Recombinant soluble pro-MT1-MMP is used as antigen for antibody generation and as antigen standard in immunoassays. The proenzyme can be activated with trace amounts of MT1-MMP catalytic domain. Active soluble MT1-MMP is used to study the activation of progelatinase A (matrix metalloproteinase 2) and the degradation of proteins of the extracellular matrix, including fibrillar collagens. Interactions with matrix metalloproteinase inhibitors can also be investigated.

Datasheet

MMP 14 (MT1-MMP) prodomain, catalytic domain, and hemopexin domain, His-tagged

MMP 14 (MT1-MMP) prodomain, catalytic domain, and hemopexin domain, His-tagged

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