Name: MLKL Polyclonal Antibody (1.5 mg/mL) for IHC, ELISA
Price: 253.00 USD

Overview
- Gene Accession: BC028141
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Fusion protein of human MLKL
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  1.5 mg/mL
  
  Antigen
  
  9130019I15Rik, FLJ34389, hMLKL, Mixed lineage kinase domain like, Mixed lineage kinase domain like protein, Mixed lineage kinase domain like pseudokinase, Mixed lineage kinase domain-like protein, Mlkl, MLKL (UniProt:Q8NB16)
  
  * For reference only.

Applications

Application

IHC; ELISA

Application	Dilutions
IHC	1:50-1:300
ELISA	1:5000-1:10000

MLKL Polyclonal Antibody (1.5 mg/mL) for IHC, ELISA

MLKL Polyclonal Antibody (1.5 mg/mL) for IHC, ELISA

Background

We Also Recommend

GALNT12 Polyclonal Antibody (1.02 mg/mL) for IHC, ELISA

HCCS Polyclonal Antibody (1.98 mg/mL) for WB, IHC, ELISA

METTL1 Polyclonal Antibody (0.6 mg/mL) for IHC, ELISA