Name: ML324
Price: 196.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    ML324 is a potent and cell-permeable JMJD2 demethylase inhibitor (IC50 = 920 nM). [1]Jumonji-domain-containing proteins (JMJD) is the largest class of N ε -methyl lysine demethylase, an enzyme that demethylates the tri-methylated H3K9. JMJD takes part in gene transcription regulation. [1]ML324 acted as an antiviral agent that effectively inhibited HSV and hCMV IE gene expression in HFF and MRC-5 cells, resulted in suppression of HSV plaques formation and inhibition of HSV infection spread. [1]ML324 also blocked HSV-1 reactivation and inhibited the formation of HSV plaque in mouse ganglia explant model of latently infected mice. [1]
    
    1.Rai G, Kawamura A, Tumber A, Liang Y, Vogel JL, Arbuckle JH, Rose NR,Dexheimer TS, Foley TL, King ON, Quinn A, Mott BT, Schofield CJ, Oppermann U,Jadhav A, Simeonov A, Kristie TM, Maloney DJ. Discovery of ML324, a JMJD2demethylase inhibitor with demonstrated antiviral activity. 2012 Dec 17 [updated 2013 Sep 16]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
- Properties
  - Alternative Name
    
    N-(3-(dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide
    
    CAS Number
    
    1222800-79-4
    
    Molecular Formula
    
    C21H23N3O2
    
    Molecular Weight
    
    349.43
    
    Appearance
    
    A solid
    
    Purity
    
    98.06%
    
    Solubility
    
    insoluble in H2O; ≥17.45 mg/mL in DMSO; ≥2.4 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Qi Zhu, Feng Liang, et al. "KDM4A regulates myogenesis by demethylating H3K9me3 of myogenic regulatory factors." Cell Death Dis. 2021 May 19;12(6):514. PMID:34011940
    2. Li N, Yang L, et al. "BET bromodomain inhibitor JQ1 preferentially suppresses EBV-positive nasopharyngeal carcinoma cells partially through repressing c-Myc." Cell Death Dis. 2018 Jul 9;9(7):761. PMID:29988031

ML324

ML324

Background

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