Name: ML-095 (hydrochloride)
Price: 282.00 USD

- Overview
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    Background
    
    ML-095 (hydrochloride) is a specific PLAP inhibitor [1]. Alkaline phosphatases are hydrolase enzymes responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. There are three isozymes of alkaline phosphatases: placental alkaline phosphatase (PLAP), intestinal alkaline phosphatase (IAP), and tissue non-specific alkaline phosphatase (TNAP). Placental alkaline phosphatase (PLAP) is highly expressed in primate placental tissue and the biological function is still unknown. However, PLAP-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers [1]. ML-095 (CID-25067483) is a biochemical inhibitor of PLAP and will be useful to elucidate the key biological functions and natural substrates of human PLAP. ML095 is a specific PLAP inhibitor and inhibited PLAP, TNAP and IAP with IC50 values of 2.1, >100 and 53 μM, respectively. ML095 exhibited greater than 25-fold selectivity over tissue non-specific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) [1].
- Properties
  - Alternative Name
    
    CID-25067483; 1-(3,4-dihydroxyphenyl)-2-(2-ethyl-1H-imidazol-1-yl)-ethanone, monohydrochloride
    
    CAS Number
    
    1135318-57-8
    
    Molecular Formula
    
    C13H14N2O3·HCl
    
    Molecular Weight
    
    282.7
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤10mg/ml in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

ML-095 (hydrochloride)

ML-095 (hydrochloride)

Background

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