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Overview
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Mithramycin A was the first of the aureolic acid class of antitumor antibiotics, isolated from Streptomyces.
Mithramycin A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.Please contact us at for specific academic pricing.
Background
Mithramycin inhibits transcription and protein synthesis by non-covalent binding with G-C-rich duplex DNA in the presence of magnesium and zinc ions. Mithramycin also induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression, and selectively inhibits collagen-1 gene expression in human fibroblasts.
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- Properties
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Overview
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