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Overview
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Background
Mirin is a potent MRN complex inhibitor. Mirin inhibits Mre11-associated exonuclease activity, rather than alters DNA-binding or MRN complex formation. Moreover, mirin prevents MRN-dependent activation of ATM in response to DNA double-strand breaks, with an IC50 value of 12 μM. The MRN complex acts as a DNA damage sensor, responsible for maintaining genome stability during DNA replication, promoting homology-dependent DNA repair and activating ATM. The MRN-ATM pathway plays an essential role in sensing and signaling from DNA double-strand breaks.
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