Mecillinam

- Overview
  - Mecillinam is a broad-spectrum β-lactam antibiotic in the penicillin class, specifically an amidinopenicillin. It was first described in 1972 (Lund and Tybring) and was developed by the Danish pharmaceutical company Leo Pharmaceutical Products (now LEO Pharma). The product is effective against Gram-negative bacteria. Mecillinam is slightly soluble in chloroform.
    
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    Background
    
    β-lactams interfere with penicillin binding protein (PBP) activity involved in the final phase of peptidoglycan synthesis. PBP’s catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid-encoded β-lactamases.
- Properties
  - CAS Number
    
    32887-01-7
    
    Molecular Formula
    
    C15H23N3O3S
    
    Molecular Weight
    
    325.43
    
    Appearance
    
    White or off-white crystalline powder
    
    Solubility
    
    Slightly soluble in chloroform. Very slightly soluble in water.
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): ≤6.0%
    Purity Level: ≥ 90.0% (by HPLC)
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Mecillinam targets primarily Gram-negative bacteria. It has minimal activity against Gram-positive organisms.
    
    Microbiology Applications: Mecillinam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.
    MIC values include:
    Escherichia coli 8 µg/mL

MSDS

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MSDS-EU

Mecillinam

Background

Documents

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