Name: MCC950 sodium
Price: 220.00 USD

- Overview
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    Background
    
    MCC950 sodium salt is a potent, selective inhibitor of NOD-like receptor family protein 3 (NLRP3) with IC50 value of 7.5 nM in bone marrow derived macrophages (BMDMs) [1].
    MCC950 effectively and selectively inhibits NLRP3 which is involved in various biological processes including autoinflammatory and autoimmune diseases. MCC950 is thus a potential therapeutic for NLRP3-associated syndromes, and a tool for the further study of the NLRP3 inflammasome in human health and disease [1].
    In BMDM and human monocyte derived macrophage (HMDM) cells, MCC950 specifically inhibited canonical and noncanonical NLRP3 activation at IC50 of 7.5 nM and 8.1 nM, respectively, without affecting absent in melanoma 2 (AIM2), NOD-like receptor family CARD domain containing protein 4 (NLRC4) or NLRP1 inflammasomes [1].
    In mice intraperitoneally injected with lipopolysaccharides (LPS), pre-treatment with MCC950 (50 mg/kg, i.p., 1 h before LPS injection) reduced serum concentrations of interleukin-1β (IL-1β) and IL-6 while it did not considerably decrease the amount of tumor necrosis factor-α (TNF-α). MCC950 attenuated the severity of experimental autoimmune encephalomyelitis [1].
- Properties
  - Alternative Name
    
    CRID3 sodium salt; sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide
    
    CAS Number
    
    256373-96-3
    
    Molecular Formula
    
    C20H23N2NaO5S
    
    Molecular Weight
    
    426.46
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥124 mg/mL in H2O; ≥21.45 mg/mL in DMSO; ≥43 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

MCC950 sodium

MCC950 sodium

Background

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